BJC is committed to publishing cutting edge discovery, translational and clinical cancer research across the broad spectrum of oncology. With its long tradition and close links with CRUK, the journal provides a global platform to disseminate important research in cancer.
This journal accepts original research articles and reviews, ranging from epidemiology, carcinogenesis and biology through to state of the art cellular and molecular approaches. Submissions should be of high scientific/clinical significance.
The British Journal of Cancer (BJC) is committed to publishing cutting edge discovery, translational and clinical cancer research. It provides a global platform for key discussions and engagement in the broad area of oncology and offers its readership high impact research across six subject categories including clinical studies, translational therapeutics, molecular diagnostics, genetics and genomics and epidemiology.
BJC is a bimonthly scientific journal with articles spanning the full spectrum of preclinical and clinical cancer research, investigation, treatment and care. It publishes original research, reviews, case reports, editorials and correspondence. It prioritises papers that make a significant contribution to the understanding of the cause and progression of cancer as well as improving patient outcomes. It is published in association with Cancer Research UK, a registered charity in the United Kingdom.
Cancer epidemiology is the study of the pattern, distribution and causes of cancer. This field includes the analysis of data from studies examining incidence, prevalence and mortality, and can be studied at the global or local level. It is also possible to examine temporal trends in these measures, or differences in them between different regions or groups of people.
The majority of cancers are caused by lifestyle factors, such as tobacco use, poor diet and insufficient physical activity, and chronic infections such as Helicobacter pylori, human papillomavirus (HPV) and hepatitis B and C viruses. Several of these are preventable by changing lifestyles and implementing screening programmes.
Cancer research is critical to our understanding of the cause of cancer and determining how best to reduce its burden. Research in the BJC covers a broad range of topics including cancer etiology, diagnosis, survival and disparities.
Immunotherapy is a treatment that uses the body’s natural immune system to fight cancer. It has seen unprecedented success in recent years, and was named Science’s “Scientific Breakthrough of the Year.” It involves boosting the immune system’s ability to detect and destroy cancer cells.
The idea of using the body’s own immune system to treat neoplastic diseases first emerged in the nineteenth century. Wilhelm Busch and Friedrich Fehleisen showed that erysipelas, an infection caused by the bacteria Streptococcus pyogenes, could result in spontaneous regression of tumours2.
Immunotherapy research has made great headway in the past decade due to discoveries on how to target neoantigens and T cell anergy. These discoveries are being translated into clinical applications, including cellular immunotherapy, oncolytic viruses and checkpoint blockade.
The genes in our cells are responsible for regulating how our bodies grow and develop. Cancer genetics is the study of mutations in these genes that help cancers form, grow and spread. These genetic changes, or variants, can be inherited from our parents or acquired by chance events during cell division.
Some inherited gene faults can cause cancer, but most cancers develop because of many other factors as well. Researchers are trying to find out more about these other factors so that we can do more to prevent cancers. They also want to know whether genetic tests for some cancers are useful in predicting how likely someone is to get the disease. The British journal of cancer publishes articles on these topics. It also has a rapid format for publishing cancer variant reports that have compelling clinical case information.
Clinical oncologists care for patients with cancer, and treat them using chemotherapy and radiotherapy. They work with other specialists and nurses in the field. They may also help patients deal with psychological issues associated with their diagnosis and treatment.
They diagnose malignancies by taking detailed medical histories and performing physical examinations. They may use X-rays, CT scanning, MRI scanning and ultrasound to localise tumours and guide biopsy. They may also use radiopharmaceuticals – such as single photon emission computed tomography (SPECT) or positron emission tomography (PET) – to identify areas of abnormal cell activity.
They treat cancer patients in hospitals and day care wards, and carry out clinics to assess new and follow-up patients. They are responsible for prescribing and organising patient treatment, which is often a combination of chemotherapy and radiation therapy.
ALDERGROVE — Almost hidden in the homes and street grid of Surrey, British Columbia is a stretch of border road known as 0 Avenue. It runs parallel to the Canada-United States border and features microwave towers and a small park.
It’s a place where families meet, hug and even share a meal across the international border. And, even though Covid-19 has closed many land crossings, this one remains open for now.
The United States Border Patrol is constructing a fence on the international border near Aldergrove. The fence will run from Boundary Road on the US side to Zero Avenue in Canada. The border is already fenced for about 1.5 miles along the Pacific Highway and another mile along the Lynden-Aldergrove border crossing. The fence will then run parallel to 0 Avenue for several more miles. It’s not clear whether the fence has anything to do with COVID-19 or other health concerns, but it could be used as a deterrent for drug smuggling and asylum seekers trying to cross illegally.
A small ditch along 0 Avenue has become a meeting place for American and Canadian families during the COVID-19 pandemic. Families gather to visit, take pictures, and feel connected across the border. Some couples even get married here. The Royal Canadian Mounted Police are stationed at the park and ask that families keep their distance from each other.
These ominous structures were once part of AT&T’s Long Lines microwave radio-relay network, which carried telephone calls and television signals coast to coast before fiber optic networks came into play. They were also hardened sites in case of a nuclear attack.
Microwave transmission does not use wires, but relies on direct line of sight between transmitter and receiver. This means that the towers are usually about 30 miles apart, though they were often farther when built in the ’50s and ’60s. You can find the towers, which are still intact with antennas pointing in different directions (to avoid signal overlap), by hunting through old maps or a Google Earth map created by a microwave-relay aficionado.
Microwave towers are still used today in remote areas for high speed trading or as backup systems to fiber when it is impractical to run a continuous wire through adverse terrain. You might even see a microwave relay tower in your neighborhood if you live in an area that has a large amount of business-to-business traffic that requires higher speeds than what fiber can provide.
Peace Arch Park
While there are a lot of great spots along the US-Canada border for road trips, few come close to the Peace Arch Park. This beautiful landmark was built to commemorate the signing of the Treaty of Ghent and the Rush-Bagot Agreement, which established a peaceful unguarded border between the United States and Canada. The 67-foot arch, which is listed on the National Register of Historic Places, is a reminder of what can happen when people of different countries work together.
The Canadian side of the park closed in June because of COVID-19 restrictions, but the American side remained open until Oct. 1. The American park is a Washington state park, while the Canadian park is owned by the Semiahmoo First Nation and accessed via Beach Road.
While the park is small, it packs a big punch in terms of international relations. At a time when borders are hardening politically but remaining physically porous, the Peace Arch Park is a symbol of cross-border connections.
A cable fence has begun to go up along a section of the international border between Canada and the United States. The American Border Patrol’s Blaine sector is overseeing the project, which appears to have nothing to do with COVID, but instead focuses on what acting chief patrol agent Tony Holladay calls bi-national safety concerns for this particular vulnerable area of the border.
The section of the border in question runs from Boundary Road north of Lynden to Zero Avenue south of Langley City. It’s a stretch of the border that has long been popular for families with loved ones in each country who can’t cross over due to the travel bans.
Usually, structures aren’t allowed within 10 feet of the border on either side. But this is a special situation, and a fence is a lot easier to see than the thorny brambles that have grown in some places to block the border. The Peace Arch Park sits right on the border, and there’s a paved pedestrian entrance into it from the Canadian side.
The British International School of Egypt is a pre-school through to year 12 British and American international school located on shr 35. The school is an independent and non-profit making school which prepares children for life through a balanced and challenging curriculum. BISC develops boys and girls who are confident and capable to take their place in a changing world.
We want our pupils to become confident, successful and responsible citizens of the world. We provide them with a broad-based education and encourage them to fulfil their aspirations, ambitions and potential in an environment which is British in style and values.
BISM is the newest school in the GEMS Education group and opened its doors in 2013. It caters to students from Pre-School through to GCSE (English National Curriculum) and Sixth Form offering both British and American sections.
We offer excellent benefits including free, well-maintained, furnished school accommodation in close proximity to the school in Madinaty or choice to claim housing allowance if you prefer your own living arrangements. BISM is also proud to be one of the few schools in Egypt that offers comprehensive medical and accident insurance for all staff and their families.
BISC strives to provide high quality education and care in an environment where all pupils are valued and encouraged to develop their full potential. We are committed to providing global educational programs complemented by comprehensive mental, physical, artistic and technical education systems that are suited for every child irrespective of their age and origin. We also aim to give children an education that will enable them to become active, responsible citizens of the world and to help them take their place confidently in a global society. BISC is a co-educational school, offering both British and American education from Foundation Stage 1 to GCSE.
The School’s curriculum design and instruction aim to meet the needs of students through a process of continuous improvement. This will include the provision of innovative instructional approaches that are both practical and progressive, and will allow for the attainment of new standards that are both relevant and challenging. The School will also provide opportunities for hands-on experiences and the development of knowledge/concepts that foster a greater understanding and appreciation of individual differences.
BISC provides an international education that is British in its character and in the way it prepares pupils for university study, leadership roles at all levels of society and for life in the global community. The school offers a full academic program complemented by comprehensive mental, physical, artistic and technical education systems.
The First Time in British History That a King Abdicated
For the first time in British history, a monarch stepped down from the throne of his own free will. Edward VIII inherited the crown from his father George V but gave it up to marry twice-divorced American Wallis Simpson.
His abdication set the stage for his niece, Queen Elizabeth II, to become Britain’s longest-serving monarch. His reign lasted 325 days.
Edward VIII’s love affair with Wallis Simpson
The scandal erupted in 1936 when Edward, who had inherited the throne from his father, George V, fell head over heels for twice-divorced American Wallis Simpson. At the time, British law and tradition barred marriages between a member of the royal family and a divorcee.
The king was determined to marry her, but the prime minister and his family refused to accept his proposal. He then offered to marry her in a morganatic marriage in which she would keep her title but not inherit the throne.
Borman, whose book about the love affair is out in February, says that the letter shows how obsessive and head over heels Edward was for Simpson. However, she suspects that Simpson was never a candidate to become queen. Her desire may have been to enjoy the attention of a wealthy man. She was, by her own admission, bored stiff by him. She reportedly enjoyed her life as the king’s mistress but did not want to be his wife.
The abdication crisis
In a matter of months, King Edward’s decision to marry a divorced commoner plunged the British monarchy into an unprecedented constitutional crisis. Prime Minister Stanley Baldwin manipulated the situation and, according to critics, used the event as an opportunity to revive his dwindling political career. The abdication crisis stripped the Crown of any remaining independent political power and guaranteed that it would never again occupy such a position in Britain.
On 11 December 1936 – ‘that dreadful day’ – he signed the Act of Abdication at Fort Belvedere, declaring that he was renouncing the throne. He left the country for France with Mrs Simpson and was demoted from ‘His Royal Highness’ to the Duke of Windsor. His exile was voluntary, but it’s highly unlikely that he will ever set foot on British soil again. It’s likely that his brother or sister will visit him occasionally, in order to maintain a semblance of family ties. His life interest in Balmoral and Sandringham will probably remain with him.
Edward’s abdication speech
The abdication crisis of 11 December 1936, the moment when Edward renounced his rights to the British throne in order to marry American divorcee Wallis Simpson, has entered the history books as one of the most dramatic episodes of the modern monarchy. It was certainly the first time that a monarch had voluntarily abdicated.
The conventional story of why he chose to abdicate is well known: he fell in love with Wallis and decided that he could not be both king and her husband. The rest is history.
Britain’s senior mandarins were alarmed by Edward’s laissez-faire attitude towards his duties and responsibilities. Warren Fisher, the head of the Home Civil Service, and Maurice Hankey, the Cabinet Secretary, both expressed concern about Edward’s handling of confidential State papers – acts of Parliament, notes of confidential diplomatic discussions, drafts of treaties, details of naval and military organisation.
Clive Wigram, the King’s private secretary, warned that Edward might soon develop into a George III.
At the start of his reign, Edward was popular with most of the Establishment – he was seen as a breath of fresh air at a time of intense unemployment and political turmoil. He was an attractive maverick with a fondness for flying in fresh fish from Fortnum and Mason, which was delivered to his French castle every morning.
The only thing that marred his reign was the scandal of his love affair with Wallis Simpson. He had sought permission from the Church of England and the Royal Family to marry the American divorcee, but they refused.
It was never quite clear if he intended to succeed his father Canute, but when he died in 1042 he became the new king with the support of his powerful ally the Earl Godwine of Wessex. At this time, there were no clearly established principles on royal succession – kinship, designation as the late king’s heir, and support from the Church and nobility all played their part.
The University of British Columbia Among the Best Universities in the World
The university’s beautiful campus is situated on a peninsula surrounded by ocean and forest. It is considered to be one of the best universities in the world.
It is also one of Canada’s top comprehensive universities. Maclean’s ranks it in the top 20 in its rankings, which include subjective reputational surveys and objective performance indicators like research funding.
1. Academic reputation
Academic reputation is a key factor that influences the performance of universities worldwide. It is measured by the number of alumni who win Nobel Prizes, have been named Rhodes Scholars and become members of the Royal Society. It is also a prominent component of the QS World University Rankings.
In order to obtain a credible academic reputation, a university must have an excellent research and teaching environment. To achieve this, the university must hire expert teachers and conduct groundbreaking research. This research must then be shared with the world. In addition, it must work with the community to make an impact on the world around it.
The academic reputation of a university is measured through the Academic Reputation Survey. This is a global snapshot of a university’s reputation, taken from the opinions of more than 100,000 academic experts. These experts are asked to name a university that they believe has excellent research in their field of expertise. The results of the Academic Reputation Survey are then used to calculate each university’s overall ranking.
2. International research network
In a new category this year, the ranking assessed universities on their international research networks. The ranking calculates this by measuring the natural logarithm of the difference between a university’s count of distinct international research partnerships and the total number of higher education institutions represented.
This was one of three categories that contributed five per cent to U-Multirank’s final tally, alongside academic reputation and employment outcomes. The ranking also included a new assessment of university sustainability, which recognized UBC’s early commitment to carbon neutrality and ongoing extensive work to reduce water and air pollution on campus and beyond.
Overall, UBC ranked 35th in the world and second among Canada’s public universities. Its strongest performance was in the academic reputation category, where it placed 11th globally – a result that is based on survey responses from scholars around the globe. The university was also lauded for its research output and the impact of that research on society, including through TRIUMF, Canada’s national lab for particle and nuclear physics.
UBC has one of the most extensive sustainability initiatives in post-secondary education. The university’s efforts on campus help reduce energy consumption, carbon emissions and waste. UBC’s Climate Action Plan 2030 includes goals to achieve a 85 per cent reduction in operational emissions, a 45 per cent decrease in extended impact sources and fostering ecological well-being on campus.
The university is also recognized internationally for its research and teaching that contributes to a sustainable future. UBC was ranked 13th in the 2022 Times Higher Education (THE) Impact Rankings for its focus on the United Nations Sustainable Development Goals.
Western was also ranked first in Canada and third worldwide in the latest Quacquarelli Symonds (QS) World University Rankings: Sustainability. The ranking evaluates how universities are working to tackle the globe’s biggest environmental, social and governance challenges by measuring their activities across two broad categories. The QS ranking examines 37 indicators in the areas of sustainable education, sustainable institutions and sustainable research.
4. Student satisfaction
UBC is known for its beautiful campus, its top notch professors and its commitment to sustainability. However, some students are not satisfied with their experience at the university. For example, some students are unhappy with the competition to get into the best programs and courses. In addition, some students are unhappy with the way they are treated by their professors and academic advisors.
Many first-year students are concerned about the financial burden of a university education. This is especially true at certain universities. One-fourth to one-third of students at these universities are very concerned about having enough funding to complete their studies.
Generally, students were satisfied with the help they received from their university in deciding on their programs and course selections. This satisfaction was higher among female students than males. Satisfaction was also higher for students intending to major in arts and humanities than for those intending to major in science. These results were similar for older and younger students.
A British Airways e ticket is a document that contains information about your flight. The e-ticket contains your flight details, seating arrangements and other essential information. This is usually displayed on your screen at check-in and is easy to read.
Seat requests are not allowed for staff travel on rebate tickets. However, the airline will assign seats based on availability.
Check-in for British Airways flights is an important part of the flight booking process. To ensure a smooth and hassle-free trip, it is recommended to check in online inside the specified time frame. Check-in times vary between airports and flights, so it is essential to know when to arrive at the airline’s website.
To begin with, visit the British Airways web page and enter your reserving reference number and last name. After profitable verification, select your flight and enter your seat selection (if applicable). You may also choose to upgrade to a premium cabin at this stage.
Once your boarding pass is ready, you can proceed to the airport and complete security checks and immigration formalities. You will need to present your passport or visa if you are traveling to a country that requires it. You should arrive at the airport a minimum of 2 hours before your flight schedule to board domestic flights and 3 hours before your flight schedule for international flights.
British Airways has a number of ways for passengers to check in, including online and at the airport. You can also use their app to get your boarding pass. Once you have checked in, it is important to arrive at the airport with plenty of time for security and boarding. You can find out the minimum check-in time for your flight by logging into Manage My Booking.
Online check-in is available 24 hours before the departure of your flight. All you need is your reference booking number and name to log in. Once you have entered your details, a boarding pass will be displayed on the website or sent to your email for download or printing.
You may want to print a boarding pass at home before arriving at the airport, especially if you are traveling with children or a companion with disabilities. This will save you time in the queue at the kiosk. You should also make sure to bring your passport and boarding pass with you to the boarding gate.
If you are travelling with baggage, British Airways has several options for you. You can check-in online, or you can do it at the airport. You may even get a free seat selection if you do it online. However, you need to be aware of the airline’s baggage allowance rules before boarding the plane.
Your baggage allowance is determined by your route and ticket type. If you’re travelling on a hand baggage only fare, you will be charged extra to check bags into the hold. You can also buy additional hold baggage in advance, if your ticket allows for it.
You can bring musical instruments on BA flights, as long as they fit into your baggage allowance. This includes wind and string instruments. You can also bring sports equipment as checked luggage. This includes tennis/squash rackets, billiard/pool cues and hockey sticks. You will need to check with the airline directly about their packing rules and fees for these items.
British Airways’ customer service representatives can help you resolve many of your flight-related issues. They can provide you with information about fares and travel dates, rebook your flights, address lost or delayed luggage, and more. However, they can’t resolve problems that are beyond their control. These include things that are a result of airport security or items that have been stolen inside an airport.
When you call British Air’s customer service, it is important to have all relevant documentation in front of you. Make sure that you have your booking reference number, last name, email address, Executive Club membership number, cancellation numbers, and billing statements.
You should also have a pen and paper handy to take notes. The representative may ask you for additional information or a few more details, so it’s best to have your documents ready. Make sure to note any areas in which the agent and you did not communicate well. This will help you identify what went wrong and how to fix it.